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In this model, ligation acts as (i) a mechanical trauma on the dentogingival area, thereby reducing tissue integrity and allowing for intense host-plaque interaction and (ii) a plaque-formation-promoting factor, thus increasing the number of bacteria

Stimulation with lipopolysaccharide (LPS) and IFN not only activated M0 macrophages into M1 phenotype but also upregulated the expression of inducible nitric oxide synthase (iNOS) in Gpx4-deficient macrophages

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Researchers chose people living with HIV because the infection is associated with accelerated biological aging