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In reality, homocysteine methylation is one of the best indicators of: Detoxification capacity Glutathione production Oxidative stress Cognitive function Mitochondrial efficiency A proper methylation blood test clarifies whether homocysteine is: Too high because of SAH buildup Too low because it cannot convert to cystathionine Disproportionate to SAM (signaling blocked methylation) Understanding these relationships prevents ineffective supplement strategies and ensures that treatment matches biochemistry, not generic protocols

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Journal of obesity & metabolic syndrome , 29 (3), 166.