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Under physiological conditions, GSH quenches oxidizing substances (such as reactive hydroxyl free radicals, peroxynitrite, and H 2 O 2 ) directly or reduces hydrogen peroxide (or lipid peroxide (lipid-OOH)) to water (or the corresponding lipid alcohol (lipid-OH)) under the catalysis of GPX (summarized in Fig

doi: 10.1152/ajpendo.00024.2006

When consumed orally, glutathione must survive the harsh acidic environment of the stomach, navigate intestinal absorption barriers, and undergo first-pass metabolism in the liver before reaching systemic circulation

Even small or occasional drinking can weaken glutathione's impact on detoxification and skin improvement

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