Writingoriginal draft preparation, YW, and MJ
As a compounding pharmacist, I find this encouraging because it shows there's active discussion around therapies that many patients and providers have been asking about
Ang-II stimulating AHMs may mitigate dementia risk by preserving AT2 receptor function, that supports memory and neurogenesis, and by blocking AT1 receptors that mediate harmful effects such as oxidative stress, amyloid accumulation, and acetylcholine inhibition 33,34,35,36
Its use is reported to result in improvement in up to 95% of patients and is especially beneficial in those with Hunner lesions
ROS are produced in mitochondria (mainly via the electron transport chain, where ~12% of O 2 is reduced to form superoxide anions), peroxisomes (through the -oxidation of fatty acids) and the endoplasmic reticulum (through the oxidation of proteins)