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Biochem J 111:431444

They can be a cause for excessive bleeding for those taking anticoagulant medication and may exacerbate symptoms if taken together continuously in large doses

These symptoms often appear when starting treatment or increasing the dose and tend to ease as the body adapts

Medication Timing and Interaction Considerations Levothyroxine must be taken on an empty stomach, at least 4 hours apart from calcium, iron, or proton pump inhibitors