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During the process of renal injury, in addition to the classical abnormal regulation of iron metabolism and lipid peroxidation, a growing number of novel metabolic pathways have also been uncovered in ferroptosis, such as the system Xc - /glutathione peroxidase 4 (GPX4) system, ferroptosis suppressor protein 1 (FSP1)/ubiquinol (CoQ10) system, dihydroorotate dehydrogenase (DHODH)/dihydroubiquione (CoQH 2 ) system, and GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4)/dihydrofolate reductase (DHFR) system ( Figure 1 )

Overdosing is rare due to vitamin B12s safety profile, though always follow prescribed dosing to avoid complications

& Mohandas, N

The following elaborates on its core applications and mechanisms in cancer research to provide references for related studies