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Experimental activation of UBE3A achieved via expression of the HPV E6/E7 oncogenesin murine fibroblasts significantly disrupted circadian oscillations, reduced BMAL1 protein levels, and increased BMAL1 ubiquitination (Gossan et al., 2014)

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Developed at Monash University in Australia, AOD9604 was designed to isolate the lipolytic activity attributed to the C-terminal region of hGH while excluding the growth-promoting and diabetogenic effects associated with the full-length hormone