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Chronic disruption of their architecture is a primary driver of metabolic alterations (Theurey and Rieusset, 2017

Circulation 2018;138:861-70

In addition to regulating blood sugar, semaglutide helps reduce hunger and promote feelings of fullness, which is especially helpful for weight loss

In the future, a multidimensional line of evidence is needed to clarify the source of GLP-1RA effects in IBD, including in vitro experiments to confirm direct actions, animal models designed to exclude metabolic interference, and clinical data adjusted for metabolic confounders

2026 ClinicalTrials.gov NCT07437547 BPC-157