Pharmacokinetic analysis Plasma concentration-time profiles were analysed in C57BL6J mice and Sprague Dawley rats by a non-compartmental method using sparse sampling in Pharsight Phoenix WinNonLin v.6.4 software, and the resulting terminal half-life ( T 1/2 ), maximum plasma concentration ( C max ), time for maximum plasma concentration ( T max ), and AUC from zero to last valid measurable concentration-time point (AUC 0-t ) were determined
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7 Initiating Toujeo in insulin-nave adults with T2D who, while on tirzepatide therapy still had an elevated HbA 1c resulted in statistically significant reductions in HbA 1c from baseline to week 24 in both primary analysis and sub-analysis groups
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