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Neuropeptide signalling proteoforms derived from VGF, somatostatin (SST) and protachykinin-1 (TAC1) showed higher abundance in AD-resilient than AD-dementia brain, whereas signalling proteoforms of cholecystokinin (CCK) and chromogranin (CHG) A/B and multiple cytoskeletal molecules were enriched in frail vs control brain

JAMA 2023;330:200015.ArticlePubMedPMC 2

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In other embodiments, the pharmaceutical formulations or compositions also contain other therapeutic substances