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Consider earlier administration (3+ hours before bed) to allow cortisol-modulating effects to establish before sleep pressure builds

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doi: 10.3389/fmed.2026.1730795 Received 23 October 2025 Revised 06 March 2026 Accepted 23 March 2026 Published 02 April 2026 Corrected 05 June 2026 Volume 13 - 2026 Edited by Andrea Tinelli, Veris Delli Ponti Hospital, Italy Reviewed by Feng Zhang, Nanjing University of Chinese Medicine, China Minghong Sun, Southwest University, China Updates Copyright 2026 Lv, Li, Ding and Kuang

Cellular Signalling Pathway Analysis Phosphorylation cascade mapping employs phospho-proteomic approaches combined with Western blot validation