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~ Genetic variants in these genes can impair energy production, especially under stress or fasting

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However, the loss of Txnip in LSEC leads to sinusoidal capillarization, downregulated NO production, and increased release of proinflammatory cytokines and adhesion molecules, and aggravates alcohol-induced liver damage, inflammation, and fibrosis ( 2.9.2 Activation of hepatic stellate cells Many studies have shown that hepatic stellate cells (HSCs) are involved in the progression of ALD through various mechanisms