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On the contrary, exogenous insulin is absorbed from the subcutaneous tissue to the peripheral circulation, resulting in relative peripheral hyperinsulinemia and hepatic hypoinsulinemia (i.e., low portal-to-peripheral insulin ratio) ( Defining IR in patients with T1D in the clinical setting is also challenging

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Furthermore, a number of studies indicate that H2O2 is synthesized in response to exogenous abscisic acid (ABA) and that H2O2 mediates, at least in part, ABA responses, including stomatal closure and gene expression (Guan et al., 2000

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