Extensive pre-clinical research has characterised Melanotan 2s central MC4R-mediated effects with studies in rodent models documenting dose-dependent effects on sexual behaviour, appetite, and autonomic regulation through hypothalamic MC4R activation
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They can also be used to prevent and treat endocrine disorders or metabolic diseases such as polycystic ovary syndrome (PCOS), obesity, and non-alcoholic fatty liver disease (NAFLD) (135)
Liang Y, Jiang F, Xu D, Fu L, Xu C, Huang G, Lin B
[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Testing meldonium: assessing soviet pragmatic alternatives to the randomized controlled trial