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4.7.3 SCFAs may alleviate GERD symptoms by supporting immune homeostasis and reducing inflammation SCFA, especially butyrate, can alter the secretion of pro-inflammatory mediators (e.g., interferon (IFN) - (IL-1, IL-2, IL-6, IL-8, tumor necrosis factor (TNF) - ) by a possible mechanism through inhibition of NF-B in intestinal epithelial cells (96, 97)

Western blot analysis demonstrated that H 2 O 2 treatment and MAPKAPK2 overexpression significantly increased p-HSP27 levels, whereas total HSP27 expression remained unchanged

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