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In addition, because the acylcarnitine ester pool in the extracellular fluid is increased following the L-carnitine infusion, L-carnitine can enter the intracellular pool for utilization before clearance [15]

What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation

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Cardiovascular Protection Studies Research reveals comprehensive cardiac protection including prevention of heart failure, normalization of elevated endothelin levels, and reduced long-term effects following myocardial infarction