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Warning signs include: Dizziness upon standing Decreased urination or dark urine Dry mouth and increased thirst Muscle weakness or cramping Other Concerning Symptoms Immediate medical attention is warranted if fatigue occurs with: Severe abdominal pain (may indicate pancreatitis) Right upper quadrant pain, fever, or yellowing of skin/eyes (signs of gallbladder disease) Persistent vomiting preventing fluid intake Visual changes or severe headache (especially in patients with diabetes and retinopathy) Chest pain or shortness of breath Signs of allergic reaction (rash, swelling, difficulty breathing) The American Diabetes Association Standards of Care recommend regular monitoring of patients on GLP-1 receptor agonists, including assessment of tolerability, glycemic control, weight changes, and overall well-being

This is particularly important for people with conditions like kidney disease or diabetes, which can impair kidney function

Tracking Hierarchy: The best way to preserve muscle while losing weight on GLP-1 drugs is to track strength performance, prioritize resistance training, and ensure adequate protein intake rather than relying solely on scale weight

For both Wegovy and Ozempic, this is 0.25 mg injected once per week