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It works at the cellular level

Produced primarily in the liver, glutathione plays a crucial role in detoxifying harmful chemicals, repairing tissues, supporting the immune system, and neutralizing free radicals that damage the skin and body cells

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A metabolite of acetaminophen also acts on the TRPV1 and TRPA1 receptors to decrease pain.[ref] While generally safe when taken as directed, higher doses of acetaminophen can lead to severe liver damage and potentially fatal liver failure