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The Metabolism Barrier When you drastically cut calories to hit a goal like 15 pounds in 30 days, your body can interpret it as a famine and enter starvation mode. This dramatically lowers your metabolism to conserve energy, making continued progress extremely difficulta phenomenon known as the plateau effect. 2

Tirzepatide was the first dual GLP-1/GIP agonist to demonstrate that adding GIP activity to GLP-1 produces additive metabolic effects in published trials [4]

This follows the recent resolution of the tirzepatide shortage ( link here )