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Long-term metformin use is associated with B12 deficiency in approximately 10-30% of patients, with risk increasing with duration of therapy and higher doses

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209 Some supplements contain P5P, which raises P5P levels and appears less likely to contribute to nerve problems than pyridoxine

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Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts Link : PubMed 25415472 Summary : In rat tendon fibroblasts, BPC-157 dose- and time-dependently increased growth hormone receptor expression, boosting cell proliferation (via MTT assay and PCNA) when combined with growth hormone, supporting tendon healing