Efficacy and safety of once-weekly efpeglenatide in people with suboptimally controlled type 2 diabetes: the AMPLITUDE-D, AMPLITUDE-L and AMPLITUDE-S randomized controlled trials
In addition, less than 30% of patients remain on treatment for more than a year 6,7,8 , and treatment discontinuation typically results in rapid weight regain 4,9,10 , with the majority of this gain attributed to increases in fat mass 11,12,13
For a subcutaneous injection, the B12 needs to be injected into the fatty tissue just below the skin
Continued support from a medical weight loss clinic helps maintain long-term results
Accordingly, inhibition of both ACC1 and ACC2 was required to improve hepatic steatosis in mice [59], implying that both isoforms are important in NAFLD