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To sum up, the amount of indirect delivery of drugs, when compared to direct delivery, is probably less, due to unexpected elimination in the body

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Immunogenic melanoma clones during the elimination phase are detected by antigen presenting cells, phagocytosed and cross-presented to melanoma specific cytotoxic T-cells for activation to induce an anti-tumor responses against melanoma associated antigens (61)

J Cell Mol Med 6 : 539553 Maulik G, Shrikhande A, Kijima T, Ma PC, Morrison PT, Salgia R (2002c) Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition