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127, No.1, pp.212-219 [online] Available at: Kamat, P.K., Mallonee, C.J., George, A.K., Tyagi, S.C

Frst P, Stehle P

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Key translational gaps therefore include determining which lactylation events are truly required drivers in vivo rather than by-products, resolving the spatial and directional relationships among lactate sources, lactylation deposition and immunosuppressive/invasive phenotypes, and establishing quantitative thresholds and stratification criteria to enable rational combination strategies (for example with immunotherapy or anti-metastatic regimens) without broadly compromising anti-tumor immune metabolism