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From a regulatory and liability perspective, this is the only position a pharmaceutical manufacturer can reasonably take

When administered either i.v., i.p., or s.c

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Epidemiological studies showed that genes contribute to the vulnerability of multiple CNS disorders, such as major depressive disorders (MDD), schizophrenia and substance use disorders with heritability respectively of 3142%, 6480%, and 2379% [10,11,12,13]

however, these observations do not represent a formal statistical comparison