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Since low serum Se levels have been found in women with preeclampsia, it has been hypothesized that low maternal Se status during early gestation may be an indicator of preterm birth

These include: Endogenous reactive metabolites such as products arising from oxidative metabolism of lipids, nucleic acids and catecholamines Xenobiotics which are not normally found in the body and can include naturally occurring compounds or they can be man made in origin such as drugs or environmental pollutants Heavy metals such as mercury, lead, cadmium and arsenic The chemical reactivity of many of these compounds cause interference with the normal biological processes and hence they are toxic

Compounds that were obscure a few years ago are entering clinical trials

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3:884 doi: 10.1038/ncomms1893 (2012)