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RE increases AR mRNA transcription via RhoA (a member of the Rho family of small GTPases which is involved in muscle transcription factor) and serum response factor (MADS-box transcription factor which is essential for muscle-specific gene expression) signaling (Lee et al., 2003)

Amano, A

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Melanocortin receptor occupancy from a single dose returns to baseline within 1822 hours, so missing one dose in a multi-week protocol has minimal impact on cumulative pigmentation outcomes

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