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PMID 28405070

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Genetic mutations that inhibit MC4R signaling cause hyperphagia, decreased energy expenditure, and early-onset severe obesity, demonstrating the receptor's fundamental importance in weight regulation

To further specify which opioid receptor subtypes were involved, selective antagonists for -, -, and -opioid receptors (-FNA, NTI, and nor-BNI, respectively) were used in combination with GHRP-2