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While the goal is to treat patients before the development of acute liver failure, treatment should still be given to patients who are found to be in active hepatic failure since NAC appears to improve hepatic perfusion and oxygen delivery, to refine mitochondrial energy metabolism, and to facilitate scavenging of reactive oxygen and nitrogen species

One study found that concomitant use of acetaminophen and alcohol resulted in a 2.23 times increased risk for kidney dysfunction (13)

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