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The descent time in pole test was shortened in BV2-metformin-loaded PLGA-treated mice compared to untreated PD-mice, and suspension test improved grip score (from 1 to 3 points)

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In addition, certain ART drugs, especially early nucleoside reverse transcriptase inhibitors, inhibit polymerase , driving mtDNA depletion and mutation accumulation that underlie toxicities such as lipodystrophy, neuropathy, and accelerated aging