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Abstract Migraine can be regarded as a conserved, adaptive response that occurs in genetically predisposed individuals with a mismatch between the brains energy reserve and workload

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A reduction in the expression of PINK1 was demonstrated to result in a significant decline in the function of the mitochondrial electron transport chain (ETC) as well as the mtDNA copy number in hepatocellular carcinoma cell lines, as evidenced in a study (Kung-Chun et al., 2019)