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The researchers measured aspects of the participants' cardiovascular health, including flow-mediated dilation (how flexible a blood vessel is), microvascular perfusion rates (how quickly and efficiently tiny blood vessels fill), blood glucose levels, and triglycerides

This paper identified the first small-molecule inhibitor of the RING-finger protein MDM2, an E3 for p53

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The rapid divergence observed in mortality, MACE, and MAKE almost immediately after the start of follow-up prompted us to explore alternative mechanisms beyond general metabolic improvements

& Wolfe, S