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There is no published pharmacokinetic data in humans, meaning we do not know how the peptide is absorbed, distributed, metabolized, or excreted

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In agreement with the expression profile of SP, it has been implicated in mood (Santarelli et al., 2001), stress (Papp et al., 2000), reward sensitivity (Thorsell et al., 2010), energy homeostasis (Karagiannides et al., 2008), pain (Hill, 2000), and learning (Huston and Hasenohrl, 1995)

Although the MASLD definition differs conceptually from traditional NAFLD criteria, multiple validation studies demonstrate high diagnostic concordance between both classification systems (810)

Eur J Clin Nutr 80 , 734737 (2026)