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The gut microbiota is essential for the development and regulation of both innate and adaptive immunity, producing bioactive metabolites such as short-chain fatty acids (SCFAs), tryptophan derivatives, and secondary bile acids, which modulate systemic inflammation and immune responses [12]

Vrang N, Larsen PJ

A subsequent multicenter Phase 2 trial in participants with overweight or obesity reported approximately 15.6% mean body weight reduction at 32 weeks with cagrilintide 2.4 mg plus semaglutide 2.4 mg, compared to roughly 5.1% with placebo and lower percentages with either monotherapy

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The four genetic defects, causing the diseases, are all inherited as autosomal recessive traits