For instance, the disproportionately high prevalence of MASLD among Hispanic populations corresponds to a higher frequency of the PNPLA3 I148M variant, which promotes triglyceride retention in hepatocytes and aggravates insulin resistance ( 2.4 Pathophysiology linking MASLD to T2DM development The link between MASLD and T2DM extends beyond mere coexistence, as both conditions share common pathophysiological mechanisms, primarily insulin resistance and compensatory hyperinsulinemia, which lead to metabolic dysfunction and -cell failure ( Figure 1 )
Increasing evidence has demonstrated that GLP-1 analogues can cross the blood-brain barrier, protect dopaminergic neurons in the substantia nigra, and rescue motor activity and cognitive functions in PD animal models (5961)
When starting semaglutide treatment, reducing the dosage of sulfonylureas or insulin can lower the risk of hypoglycemia
However, causal relationships have yet to be established, and further investigation is needed to confirm their therapeutic potential
This results in maintaining optimum levels in Type-2 Diabetes patients
