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Of the included studies, five were RCTs [20,21,22,23,24] and five were cohort studies [25,26,27,28,29]

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doi: 10.1007/s11869-021-01146-z 20

Subsequent trials demonstrated cardiovascular benefits: in the SUSTAIN 6 trial, semaglutide reduced major adverse cardiovascular events by 26% in high-risk patients, a finding that led to FDA approval for cardiovascular risk reduction in January 2020