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Naltrexone/bupropion (Mysimba) is contraindicated in end-stage renal disease and requires dose reduction in moderate renal impairment, as specified in its Summary of Product Characteristics

Statistical analysis The data analysis was performed using GraphPad Prism 6.0, and the results were presented as means SD

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Glycogen synthase kinase-3 is an intermediate modulator of serotonin neurotransmission