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What Berberine Can and Cannot Do Berberine is a plant-derived compound found in goldenseal, barberry, and Oregon grape root

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Theodorakis N, Nikolaou M

Understanding this dual role has important therapeutic implications, as G protein-biased GLP-1 receptor agonists with reduced -arrestin recruitment show enhanced anti-hyperglycemic efficacy through avoidance of receptor desensitization, while the requirement for -arrestin-2 in ERK/CREB activation at therapeutic concentrations explains why complete elimination of -arrestin-2 recruitment may not be optimal for all applications