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For example, the team led by Hai Wang has developed nanoscale mitochondrial inducers (mitoNIDs) that selectively eliminate mitochondria in tumor cells, reduce ROS levels in the TME, and restore the metabolic activity and function of CD8T cells [89]

Evidence also indicates that not the parent drugs, but their metabolites may be ultimately responsible for mitochondrial toxicity, emphasizing the importance of drug metabolism

Adaptations in brain reward circuitry underlie palatable food cravings and anxiety induced by high-fat diet withdrawal

However, gastrointestinal adverse events (AEs) remain a known limitation and have constrained dose levels in earlier clinical trials

It is also thought to increase athletic performance