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This research was funded by the National Natural Science Foundation of China (grant number 82104766), the Hunan Provincial Natural Science Foundation (grant numbers 2024JJ5313 and 2025JJ80981), the Health China-Buchang Zhiyuan Heart and Brain Health Public Welfare Project (grant number HIGHER2023041), and the Hunan University of Chinese Medicine Graduate Innovation Project (grant number 2024CX114)