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Thus, the half-life of superoxide, although very short at high concentrations (e.g., 0.05 seconds at 0.1mM) is actually quite long at low concentrations (e.g., 14 hours at 0.1 nM)

Caloric restriction plays a central role

Severe symptoms include inability to eat or drink, rapid weight loss beyond expected levels, persistent vomiting, or signs of dehydration like dizziness or dark urine

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