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Creatine, CoQ 10 and their combination block MPTP-induced lipid peroxidation and -synuclein accumulation In order to determine if neuroprotective effects of creatine, CoQ 10 and the combination of the both compounds can block MPTP-induced oxidative damage and increase in -synuclein accumulation, we examined MDA, which is a marker for lipid peroxidation, and -synuclein immunostaining in SNpc

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The methodological quality of the included studies was assessed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool for assessing risk of bias [19]