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It is released from the L-cells of the small intestine and binds to specific GLP-1 receptors that are expressed in various tissues including pancreatic beta cells and pancreatic ducts [55,56]

406 When GLP-1R is knocked out in astrocytes, it activates an integrated stress response, which affects the overall metabolic state by increasing the production of FGF21

The defense covers the benefits of Ozempic and Mounjaro and addresses the plaintiffs claim of failure to warn for GLP-1RAs