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The triple therapy of metformin, a DPP-4 inhibitor and a SGLT-2 inhibitor has a very low treatment related hypoglycaemia risk, leads to a further, almost additive reduction of glycaemic parameters, a body weight loss in the same range as with a mono- or dual therapy with a SGLT-2 inhibitor and also to the expected SGLT-2 inhibitor induced reduction of blood pressure

However, these challenges are not unique to this domain and mirror those faced by other peptide systems prior to successful translation

Angiotensin II stimulates DNA synthesis of rat pancreatic stellate cells by activating ERK through EGF receptor transactivation

Or even something as simple as a variation in label color could go a long way

This ensures that a fresh, stable aliquot is available for each experiment, preserving the peptide's bioactivity