It also forms when frying foods in oil at high temperatures.[ref] Reducing oxidative stress: In addition to their role in removing toxicants, the GST enzymes are also important for neutralizing reactive oxygen species (ROS) which cause oxidative stress in cells.[ref][ref] Genetic variants that decrease GST enzyme function increase the susceptibility to diseases that are caused by oxidative stress, such as neurodegenerative diseases, cancers, epilepsy, and ataxia.[ref] What happens when you have reduced GST function

Treatment with Fer-1, Lip-1, or neural stem cell-derived extracellular vesicles enriched in CDC42 substantially attenuates cerebrovascular damage and cognitive deficits in PD mice ( + treatment significantly reduces TIGAR expression in HT22 cells, downregulates NADPH, GPX4, and GSH levels, upregulates GSSG levels and the GSSG/GSH ratio, decreases adenosine triphosphate (ATP) production, and promotes neuronal ferroptosis, iron-dependent lipid peroxidation, and mitochondrial dysfunction, thereby exacerbating neuronal cytotoxicity
"Phylogenetic origins for severe acetaminophen toxicity in snake species compared to other vertebrate taxa"
Over time, this cumulative oxidative stress impairs mitochondrial function, disrupts cell signaling, and promotes inflammation - all hallmarks of biological aging
Research peptide studied for its potential role in cognitive performance, neuroprotective activity, and neurotransmitter-related pathways