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Dosing calculations translate directly to therapeutic exposure

c-MET can either act as an immunosuppressive agent by negatively affecting dendritic cells (DC) and T lymphocytes or can stimulate immune response by promoting recruitment of DC, B-cells and T-lymphocytes [70]

Ocak and colleagues [39] found an increased risk of venous thrombosis in MS patients: the OR for venous thrombosis in MS was 2.4 (95 % CI 1.34.3), and the OR increased to 12.5 (95 % CI 1.5-107.9) in patients with both MS and increased factor VIII levels, which indicates the additional risk factor of thrombophilia

Each 0.25mL injection delivers exactly 5mg

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