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Natural compounds like midazolam, vitamin B12, metformin, Cangrelor, and hesperidin have also shown anti-inflammatory effects in preclinical MIRI models, often by modulating macrophage polarization or inhibiting inflammatory pathways like NF-B (Huang et al., 2020
Brand-name formulations include Ozempic, Wegovy, and Rybelsus
DA4-JC perhaps deserves special consideration in the treatment of AD/PD as it has been shown to cross the BBB effectively, superior to DA3-CH [21]
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Today, however, we are surrounded, bombarded even, with highly and ultra-processed foods everywhere, ready at the touch of a button or a quick trip to the store
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