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First, it was reported that the mechanism of C-cell transformation in rodents is by activation of the GLP-1 receptor on the C cell, and a study has shown that GLP-1 receptor stimulation is a better predictor of C-cell hyperplasia than plasma drug concentrations of exenatide and liraglutide ( In the analysis of different types of GLP-1 receptor agonists, we found that liraglutide and dulaglutide were significantly associated with an increased risk of overall thyroid disorders

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These features support the rationale for using glucagon in combination with other gut hormones as described below