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Description IGF-DES (Des(1-3) IGF-1) IGF-DES, also known as Des(1-3) IGF-1, is a truncated analog of insulin-like growth factor-1 lacking the first three N-terminal amino acids that researchers have identified as significantly more potent than full-length IGF-1 due to reduced binding to IGF binding proteins (IGFBPs)

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The medication's weight loss effects are primarily driven by appetite suppression through central nervous system effects, with the gastric emptying delay contributing to early satiety

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Julia Zumpano, a registered dietitian at the Cleveland Clinic in Ohio, added that focusing on a single food or drink ignored the many other factors that played a role in weight loss