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In terms of efficacy, this double pack has its hands tied

doi: 10.1016/j.brainres.2009.05.009 147 YingM.YouD.ZhuX.CaiL.ZengS.HuX

In adaptive immunity, PXR functions predominantly as a negative regulator by suppressing T lymphocyte activation and proliferation, limiting interferon- (IFN-) production, and restraining B-1 cell development (82, 83)