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Human evidence note: While practitioner reports and early clinical experience are accumulating, large, controlled human trials are still limited

The keywords (((semaglutide) AND (tirzepatide)) AND (weight loss)) AND ((outcomes) OR (efficacy)) were used to perform the systematic review search

More recently, sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been demonstrated to improve exercise capacity in patients with HFpEF [102]

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Full details in the generic semaglutide guide